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Ledifos
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Hetero Healthcare Ltd. (INDIA)

Ledifos


“Ledifos” is a fixed-dose combination of “Ledipasvir and Sofosbuvir” which are direct acting antiviral agents against the hepatitis C virus (HCV). Ledipasvir is an inhibitor of the protein, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active Uridine analog triphosphate which can be incorporated into HCV RNA and acts as a chain terminator.


Indication

Ledifos is used for the treatment of chronic hepatitis C virus (HCV).

Cure rates are 94% to 99% in people infected with genotype 1 (46% of HCV cases). It has also been evaluated for the treatment of infection with other Hepatitis C genotypes, and has shown promising results in genotypes 3 and 4.

Note

SIDE EFFECT :

  • Common side effects include muscle pains, headache, nausea, rash, diarrhea, insomnia and cough.
  • More severe reactions are connected with allergic reactions to the medications and cardiovascular problems.

INTERACTIONS :

  • Patients are advised to stay away from H2 Receptor Antagonists (H2RA) and Proton Pump Inhibitors (PPI) because they decrease the concentration of Ledipasvir.
  • Ledipasvir / Sofosbuvir should additionally be avoided when taking amiodarone or other drugs that lower heart rate; there is a serious risk of the heart slowing or stopping when Ledipasvir / Sofosbuvir is used with such drugs.

OVERDOSE :

  • Do not use more than prescribed dose.
  • If you suspect you may have overdosed, call your healthcare provider.
  • Do not take extra dose to make up for the missed dose.

 

 

Precaution

  • Ledifos is a prescription drug and should be used under proper medical guidance and advice.
  • Do not use Ledifos if you are pregnant or breastfeeding or trying to get pregnant.
  • Ledifos is contradicted for use during unprotected sexual intercourse as it may also lead to birth defects.
  • Ledifos is not to be taken within a before and after 4 hour period of taking any Antacids

Updated On Oct 17, 2019 by Admin

Strength

90 mg Ledipasvir /400 mg Sofosbuvir

Packing

1 X 28 Tablets (Plastic Container)

Storage

Store at a temperature not exceeding 30 C



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